Cognitive deficits in youth with familial and clinical high risk to psychosis: A systematic review and meta-analysis

E Bora; A Lin; SJ Wood; AR Yung; PD Mcgorry; C Pantelis

Journal article

Cognitive deficits in youth with familial and clinical high risk to psychosis: A systematic review and meta-analysis

E Bora, A Lin, SJ Wood, AR Yung, PD Mcgorry, C Pantelis

Acta Psychiatrica Scandinavica | Published : 2014

DOI: 10.1111/acps.12261

Abstract

Objective: It is likely that cognitive deficits are vulnerability markers for developing schizophrenia, as these deficits are already well-established findings in first-episode psychosis. Studies at-risk adolescents and young adults are likely to provide information about cognitive deficits that predate the onset of the illness. Method: We conducted meta-analyses of studies comparing familial-high risk (FHR) or ultra-high risk (UHR; n = 2113) and healthy controls (n = 1748) in youth studies in which the mean age was between 15 and 29. Results: Compared with controls, high risk subjects were impaired in each domain in both UHR (d = 0.34-0.71) and FHR (d = 0.24-0.81). Heterogeneity of effect s..

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University of Melbourne Researchers

Stephen Wood Author

Patrick McGorry Author

Christos Pantelis Author

Related Projects (3)

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

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RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Grants

Funding Acknowledgements

Prof Christos Pantelis and Prof Patrick McGorry were supported by a National Health and Medical Research Council of Australia (NHMRC) Program Grant (ID: 566529). Prof Christos Pantelis was also supported by a NHMRC Senior Principal Research Fellowship (ID: 628386).